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Jizhong Zou Selected Research

Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase

10/2021Generation of two gene corrected human isogenic iPSC lines (NCATS-CL6104 and NCATS-CL6105) from a patient line (NCATS-CL6103) carrying a homozygous p.R401X mutation in the NGLY1 gene using CRISPR/Cas9.
1/2019Generation of an induced pluripotent stem cell line (TRNDi002-B) from a patient carrying compound heterozygous p.Q208X and p.G310G mutations in the NGLY1 gene.
1/2019An induced pluripotent stem cell line (TRNDi010-C) from a patient carrying a homozygous p.R401X mutation in the NGLY1 gene.

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Jizhong Zou Research Topics

Disease

4Inborn Genetic Diseases (Disease, Hereditary)
10/2021 - 01/2019
3NGLY1 deficiency
10/2021 - 01/2019
3Sickle Cell Anemia (Hemoglobin S Disease)
01/2020 - 08/2008
3Chronic Granulomatous Disease
01/2017 - 05/2011
2Cardiotoxicity
10/2022 - 01/2019
2Mucopolysaccharidosis II (Hunter Syndrome)
01/2022 - 01/2019
2Glycogen Storage Disease Type II (Pompe's Disease)
12/2020 - 01/2019
2Lysosomal Storage Diseases (Lysosomal Storage Disease)
01/2019 - 01/2019
2Cardiomyopathies (Cardiomyopathy)
01/2019 - 12/2018
1Ischemia
10/2022
1Hypoxia (Hypoxemia)
10/2022
1Alagille Syndrome (Alagille-Watson Syndrome)
01/2021
1Anemia
01/2021
1Macrocytic Anemia
01/2021
1Pure Red-Cell Aplasia
01/2021
1Diamond-Blackfan Anemia (Anemia, Diamond Blackfan)
01/2021
1Farber Lipogranulomatosis
01/2021
1Type C Niemann-Pick Disease (Niemann Pick Disease, Type C)
01/2020
1Pain (Aches)
01/2020
1Mucopolysaccharidoses
01/2019
1Mucopolysaccharidosis III (Sanfilippo Syndrome)
01/2019
1Neoplasms (Cancer)
01/2019
1X-Linked Genetic Diseases
01/2019
1Left Ventricular Dysfunction
01/2019
1Type B Niemann-Pick Disease
01/2019
1Type A Niemann-Pick Disease
01/2019
1Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis)
10/2018
1Tay-Sachs Disease
01/2018
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2018
1Wolman Disease (Wolman's Disease)
01/2017
1Ventricular Remodeling
01/2017
1Macular Degeneration (Age-Related Maculopathy)
01/2016
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
07/2015
1Schizophrenia (Dementia Praecox)
11/2014
1Mental Disorders (Mental Disorder)
11/2014
1Teratoma (Teratoid Tumor)
07/2014

Drug/Important Bio-Agent (IBA)

5Pharmaceutical PreparationsIBA
10/2022 - 01/2016
5Proteins (Proteins, Gene)FDA Link
01/2020 - 11/2014
4AcidsIBA
12/2020 - 01/2019
3Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine AmidaseIBA
10/2021 - 01/2019
3GlobinsIBA
01/2021 - 10/2011
3Reactive Oxygen Species (Oxygen Radicals)IBA
01/2017 - 05/2011
2Doxorubicin (Adriamycin)FDA LinkGeneric
10/2022 - 01/2019
2alpha-Glucosidases (Acid Maltase)IBA
12/2020 - 01/2019
2Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA
01/2019 - 01/2019
2Oxidoreductases (Dehydrogenase)IBA
01/2015 - 05/2011
1eltrombopagFDA Link
01/2021
1Jagged-1 ProteinIBA
01/2021
1Heme (Haem)IBA
01/2021
1Ribosomal Proteins (Ribosomal Protein)IBA
01/2021
1GlycogenIBA
12/2020
1cholesterol-binding proteinIBA
01/2020
1Glycoproteins (Glycoprotein)IBA
01/2019
1Iduronic Acid (Iduronate)IBA
01/2019
1NucleotidesIBA
01/2019
1Acetylglucosaminidase (NAGase)IBA
01/2019
14-nitrophenethyl bromide (NPB)IBA
01/2019
1alpha-N-acetyl-D-glucosaminidase (alpha-N-acetylglucosaminidase)IBA
01/2019
1HydrolasesIBA
01/2019
1Mitochondrial DNA (mtDNA)IBA
01/2019
1Hexosaminidases (Hexosaminidase)IBA
01/2018
1LipidsIBA
01/2018
1CyclodextrinsIBA
01/2018
1Tocopherols (Tocopherol)IBA
01/2018
1Therapeutic UsesIBA
01/2018
1Hexosaminidase A (Hex A)IBA
01/2018
1TunicamycinIBA
01/2017
1Sterol Esterase (Hormone-Sensitive Lipase)IBA
01/2017
1Transcription Factor CHOPIBA
01/2017
1Retinaldehyde (Retinal)IBA
01/2016
1Chimeric Antigen ReceptorsIBA
07/2015
1EnzymesIBA
01/2015
1Biological ProductsIBA
11/2014
1enhanced green fluorescent proteinIBA
07/2014
14- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA
05/2011
1Zinc Finger NucleasesIBA
05/2011
1Sickle HemoglobinIBA
08/2008

Therapy/Procedure

5Therapeutics
01/2022 - 01/2017
1Cell- and Tissue-Based Therapy (Cell Therapy)
12/2018
1Enzyme Replacement Therapy
01/2018